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Fungus Toe Nail

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Onychomycosis is the medical term that is used to describe a fungal infection of the toe or finger nail. It is estimated that 40 million Americans suffer from onychomycosis. The organism that causes onychomycosis is usually fungus (90% of cases) or yeast (7% of cases).

onychomycosisOnychomycosis is a fungal infection that is unrelated to foot hygiene. No matter how clean you keep your feet, you are still at risk for a fungal infection of the skin and nail. There are several ways in which we contribute to the onset of onychomycosis. First, as a civilized society we wear shoes. Shoes create an environment that is wonderfully conducive to the growth of fungus. The environment inside a shoe is dark, warm and damp. That environment is perfect for the growth of fungus. Second, any form of trauma to the nail will enable fungus to enter the space beneath the nail and begin an infection.

It is safe to say that 50% of folks over the age of 50 show clinical signs of onychomycosis. But this doesn't necessarily mean thatonychomycosis onychomycosis is due to 'old age'. This simply implies that with the passage of time there is a greater tendency to acquire a fungal infection of the nail. Trauma makes the nail much more susceptible to fungal infections. An injury to the nail is a common precursor to a fungal nail infection. It's also reasonable to assume that folks in professions that abuse their feet would tend to have a higher rate of onychomycosis. Trauma may be something abrupt such as a can of soup hitting the nail from the top shelf or something as benign as a pair of ill-fitting shoes constantly rubbing on the nail. Onychomycosis is also very common in runners.

onychomycosisThe appearance of onychomycosis can vary but most cases begin at the distal tip of the nail and slowly progress into the nail over a period of months to years. This classic onset of onychomycosis is called distal subungual onychomycosis. The nail will thicken as the fungus continues to grow. The filaments of fungus take up space in the nail causing it to swell. The nail can be yellow, white or even green to black. The nail also begins to be chalky, flakey and will separate from the underlying nail bed.

Treatment of toe nail fungus and onychomycosis

Prevention of injuries to the nail is a very important aspect of preventing fungal nail infections. Preventative measures include:

  • Avoid injuries to the nails. Protect the feet with enclosed shoes or steel toe boots.

  • Keep the feet dry with frequent changes of socks and use of talc or baby powder. Rotate shoes to let them dry for 48 hours between use.

  • Purchase shoes with a toe box the shape of your foot. When purchasing shoe, stand barefoot next to the new shoes and see how the shape of your foot compares to the toe box of the shoe. Try to match the shape of the toe box to the shape of your foot.

Medications for onychomycosis fall into two categories; topical and oral. There are any number of effective topical antifungal medications available over the counter. Topical medications are most helpful in treating early infections and for maintaining clear nails. Topical medications are fungistatic meaning that they inhibit the growth of the fungus. By limiting the growth rate of the fungus, the nail is then able to grow faster than the invading fungus infection. Remember, fungus doesn't take a day off. Compliance is a big issue when using topical antifungals. It can often take several months before results are seen.

The older generation of oral antifungal medications, which includes medications such as Fulvicin or Griseofulvin, have been used successfully for years and are making a comeback due to their economic value. The newer generation of oral antifungals, including Sporanox and Lamisil, have been received very well by the medical community. These medications should only be taken under the care of your doctor due to potential hepatic toxicity.

It's important to note that one of the characteristic findings of fungal nail infections is the separation of the nail from the underlying nail bed. Topical and oral medications are in part limited in their efficacy in that they can treat the fungal infection of the nail but they are not able to reattach the nail to the nail bed. Separation of the nail from the nail bed occurs in advanced cases of onychomycosis. Therefore, the success or failure of these medications in their ability to return the appearance of the nail to 'normal', can be limited by how advanced the nail infection is at the onset of treatment.

nail_surgery_post_opWhen all else fails, the fungal toe nail can be permanently removed. This procedure is an office based procedure and most patients return to their normal shoes in just a Band-Aid within 24hrs. The removal of the fungal to nail is permanent. Following permanent avulsion of the nail, the operative site heals over with skin that can be painted with nail polish as seen at left.

Which treatment choice is right for you? Consider the following two examples;

Case 1. Sandy is a 24 year old hairdresser who has intimate hands on contact with her clients on a daily basis. She has developed a fungal infection in several of her finger nails. She is concerned that the fungal infection will have a direct impact on her livelihood and does not want to spread the infection to others. In this case, Sandy's fungal infection may directly affect her job. In this case, the use of an oral antifungal may be indicated.

Case 2. Joe is a 62 year old farmer and has a long history of injuries to his hands and feet. His last visit to the doctor showed signs of an increase in his liver enzyme studies indicating an overall decrease in his liver function. Joe has developed onychomycosis in most of his toe nails. Joe would not be a candidate for oral antifungal medications. In fact, Joe may not be a candidate for treatment at all. Periodic debridement of the nail may be all that is necessary.

Case 3. Irene is a 42 y/o single mom who works in an office setting. Recently she has noticed a yellow discoloration of several of her toenails. Irene is beginning to see the onset of onychomycosis. Irene would be a great candidate for topical antifungal nail medications.


Nomenclature:

Beau's lines - deep longitudinal grooves in the nail plate

Eponychium - thin layer of skin overlying the matrix at the base of the nail

Koilonychia - spoon shaped nails

Lunula - a small white moon shaped area at the base of the nail. The purpose of the lunula is not clear but it appears to be an extension of the nail matrix.

Matrix - the cells beneath the eponychium that produce the nail

Onychocryptosis - onycho is derived from Greek and refers to any nail condition. Crypt, or to bury is combined to form a word that describes an ingrown nail where the nail is buried in the nail fold. This term can be used to describe an ingrown nail both with or without an infection.

Onychomycosis - a fungal nail infection

Paronychia - para refers to parallel. Onychia is derived from Greek and refers to nail. Paronychia is a condition that present with pain along the entire border (parallel to) of the nail. This term is often used to describe chronic pain at the edge of the nail with or without an infection. This term is also used to describe irritation form the nail at the base of the nail.

Pincer nails - nails that are pinched

Splinter hemorrhages - small bruises beneath the nail plate. Common to endobacterial carditis or atrial fibrillation.

Subungual - beneath the nail

Subungual exostosis - a bone spur beneath the nail

Subungual hematoma - dark discoloration of the nail due to bruising beneath the nail

Ungual - refers to nail


Anatomy:

cross-sectional_anatomy_of_the_toe_and_toe_nailNail is an elastic, transparent layer of keratin. It is surrounded on two sides by soft skin referred to as the periungual folds. The base of the nail is called the eponychium and the distal tip of the nail is called the hyponychium. Nail cells are created in a small envelope called the nail matrix.


Biomechanics:

No information is available for this topic.


Symptoms:

The symptoms of a fungal nail infection can vary. Pain can be chronic due to a low grade mechanical irritation of the periungual folds or be acute due to a foreign body reaction by the skin adjacent to the nail. When the skin adjacent to the nail perceives the nail to be a foreign object, it will mount a response to push out the nail, just as the skin would respond to a splinter. This response is usually a low grade soft tissue infection.

Fungal infections of the nail are not by themselves painful. As the nail thickens, pressure from shoes and adjacent toes will put pressure on the skin surrounding the toe nail resulting in pain and possible soft tissue infections.


Differential Diagnosis:

The differential diagnosis for this condition should include;

Bone spur, subungual (beneath the nail).

Lister corn or callus adjacent to the nail.

Malignant melanoma.

Onychocryptosis - (ingrown nail)

Psoriatic nail arthritis

Wart


Products Recommended for Fungus Toe Nail:

See Also:

References:

This article was written by Jeffrey A. Oster, DPM and last updated 2/6/13.

Additional references include;

Elewski BE: Diagnostic techniques for confirming onychomycosis. J Am Acad Dermatol 35 (3 Pt 2): S6, 1996

Scherer WP, Kinmon KK; Dermatophyte test medium culture versus mycology laboratory analysis for suspected onychomycosis. JAPMA 90:9 2000McCarthy

DJ: Origins of onychomycosis. Clin Podiatric Med Surg 12:221, 1995

Habif TP: Nail diseases in Clinical Dermatology, 3rd edition, p 765 CVMosby, St. Louis, 1996


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